albumin-bound paclitaxel yog dab tsi?

albumin-bound paclitaxel yog dab tsi?Albumin-bound paclitaxel (feem ntau hu ua albumin paclitaxel, tseem hu ua Nab-P) yog ib qho tshiab paclitaxel nanoformulation, uas yog thoob ntiaj teb lees paub tias yog cov txheej txheem siab tshaj plaws ntawm paclitaxel.Nws ua ke endogenous tib neeg albumin nrog paclitaxel nyob rau hauv ib daim ntawv uas tsis yog-covalent thiab cov nanoparticles tshwm sim kiag li kov yeej qhov tsis zoo ntawm paclitaxel yog insoluble nyob rau hauv dej, tsis tas yuav tsum tau rau polyoxyethylene castor roj los yog Tween 80 raws li ib tug co-solvent.Raws li albumin yog cov khoom lag luam endogenous, nws muaj qhov zoo ntawm kev nyab xeeb, tsis muaj tshuaj lom, tsis muaj tshuaj tiv thaiv kab mob, biodegradable, thiab biocompatible.

Vim li cas albumin-bound paclitaxel yog qhov siab tshaj plaws?

1. Tsis muaj co-solubilizationno ua ntej kev kho mob

Txais plasma protein ntawm lub hauv paus chiv keeb, nws khi hydrophobic paclitaxel molecules nyob rau hauv ib tug non-covalent daim ntawv uas tsis muaj co-solvent, tshem tawm cov hypersensitivity thiab toxicity tshwm sim los ntawm co-solvents, yog li tshem tawm qhov xav tau rau cov tshuaj hormone pretreatment ua ntej siv thiab shortening lub infusion lub sij hawm. mus txog 30 feeb, ua kom luv luv hauv tsev kho mob ntawm cov neeg mob oncology, thiab txawm ua tiav cov tshuaj khomob los ntawm chaw kho mob hnub.

2. Cov tshuaj pharmacokinetics zoo dua

Piv nrog cov paclitaxel cov pa, albumin paclitaxel muaj cov ntaub so ntswg sai dua thiab ntau dua hauv lub cev, nrog rau kev tso tawm qeeb qeeb los ntawm cov ntaub so ntswg, cov koob tshuaj tiv thaiv kab mob hauv tib neeg lub cev tuaj yeem nce ntxiv thiab cov txiaj ntsig kho tau zoo tuaj.

3. Xaiv cov qog nqaij hlav hauv zos

Ib qho laj thawj uas vim li cas ntau tus neeg mob ntshai ntawm paclitaxel chemotherapy yog tias kev faib cov paclitaxel ib txwm nyob hauv cov ntaub so ntswg thiab lwm cov ntaub so ntswg yog qhov pib zoo ib yam, ua rau muaj kev phiv loj heev.Hauv qhov sib piv, paclitaxel muaj qhov txuj ci tseem ceeb "kev xaiv cov qog noj ntshav hauv zos" thiab nws cov concentration hauv cov qog nqaij hlav ntau dua li lwm cov ntaub so ntswg.

Nco tseg: Cov txiaj ntsig zoo thiab cov ntawv thov tau piav qhia hauv kab lus no yog muab los ntawm cov ntaub ntawv luam tawm.

Yunnan Hande Bio-Tech Co., Ltd tau tshwj xeeb hauv kev tsim khoom ntawmPaclitaxel APIrau ntau tshaj 20 xyoo, thiab yog ib lub ntiaj teb ua lag luam ntawm paclitaxel API nrog FDA pom zoo, CEP daim ntawv pov thawj thiab GMP daim ntawv pov thawj hauv Suav teb.Hande tuaj yeem muab tsis tau tsuas yog zoo paclitaxel API tab sis kujKev pabcuam kev pabcuam rau paclitaxel albumin.Yog xav paub ntxiv, thov hu rau peb ntawm 18187887160.