Paclitaxel, ib yam khoom ntuj muab rho tawm los ntawm liab fir, inhibits qog cell mitosis los ntawm kev ua ntawm microtubule proteins.Nws yog ib tus neeg sawv cev ntawm cov chav kawm paclitaxel thiab yog thawj cov tshuaj tshuaj los ntawm cov nroj tsuag ntuj tau txais kev pom zoo los ntawm FDA rau kev kho mob ntawm ntau hom qog noj ntshav, suav nrog zes qe menyuam, lub mis, lub ntsws, Kaposi's sarcoma, qog nqaij hlav hauv tsev menyuam thiab pancreatic cancer.Nyob rau hauv xyoo tas los no,paclitaxelkuj tau txais koob meej rau nws siv hauv cov cuab yeej kho mob.Cia wb mus saib nws hauv kab lus nram qab no.
Kev siv ntawmpaclitaxelhauv cov khoom siv kho mob
Paclitaxel, los ntawm ib txhij polymerization nrog α (α-tubulin) thiab β (β-tubulin) ntawm microtubulin, ua rau ntau tus microtubules rau polymerize txawv txav, ua rau kev hloov pauv ntawm lub cev sib npaug ntawm cov hlwb thiab poob ntawm kev ua haujlwm ib txwm muaj, ua rau txoj kev loj hlob ntawm tes nres hauv G0 / G1 theem thiab G1 thiab GM theem, thiab cell mitosis yuav tsum tau tiv thaiv nyob rau hauv mitotic theem, thaum kawg ua tiav cov inhibition ntawm vascular du leeg division, proliferation Qhov tshwm sim yog inhibit qhov kev faib thiab proliferation ntawm vascular du nqaij. thiab tiv thaiv restenosis tsis tshwm sim.
1. Paclitaxeltshuaj stent
Drug-eluting stent (DES) yog ib qho stent uas siv cov hlau liab qab stent platform los nqa (nqa) tshuaj tiv thaiv kab mob endothelial proliferation, uas yog tso tawm los ntawm lub zos elution nyob rau hauv lub nkoj kom zoo inhibit endothelial proliferation thiaj li yuav tiv thaiv restenosis nyob rau hauv lub stent.Kev siv cov tshuaj eluting stents ua tau zoo txo qis qhov tshwm sim ntawm restenosis thiab rov cuam tshuam, tab sis tsis txo tus nqi ntawm kev mob thiab kev tuag.Tsis muaj qhov sib txawv tseem ceeb hauv qhov xwm txheej ntawm qhov chaw kho mob kawg ntawm cov tshuaj siv tshuaj tua kab mob, nrog rau qee qhov kawg ntawm qhov kawg tau txais txiaj ntsig.Drug-eluting stents muaj xws li liab qab stents ua los ntawm stainless hlau los yog cobalt-chromium uas yog them nrog antiproliferative tshuaj nqa nrog polymeric tshuaj xa coatings xws li mus tas li, biodegradable, thiab polymer-free tshuaj xa txheej technologies, thiab muaj cov tshuaj xws li limoxylates thiab paclitaxel.Tam sim no, paclitaxel tshuaj stents feem ntau yog siv rau hauv kev kho mob ntawm ntau yam kab mob ntawm coronary, intracranial, carotid, raum thiab femoral hlab ntsha.
2. Paclitaxel tshuaj-coated balloons
Drug-coated balloon (DCB), raws li cov txheej txheem tshiab thiab paub tab, tau ua pov thawj hauv ntau qhov kev sim tshuaj rau nws txoj kev ua tau zoo thiab kev nyab xeeb hauv ISR, intracoronary stenosis lesions, me me hlab ntsha tawg, bifurcation lesions, thiab lwm yam.
Nco tseg: Cov kev ua tau zoo thiab kev siv tau piav qhia hauv kab lus no yog muab los ntawm cov ntaub ntawv luam tawm.
Kev nyeem ntawv txuas ntxiv:Yunnan Hande Biotechnology Co., Ltd. tau tsom mus rau kev tsim cov paclitaxel rau 28 xyoo.Nws yog lub ntiaj teb thawj tus neeg ua haujlwm ywj pheej ntawm cov nroj tsuag-derived anticancer tshuaj paclitaxel uas tau pom zoo los ntawm US FDA, European EDQM, Australian TGA, Tuam Tshoj CFDA, Is Nrias teb, Nyiv thiab lwm lub tebchaws tswj hwm.kev lag luam.Yog xav yuavPaclitaxel API, thov hu rau peb hauv online.
Post lub sij hawm: Oct-09-2022