Cov tshuaj Paclitaxel tau raug suav hais tias yog thawj kab kev kho mob cancer mis, thiab tau siv dav hauv kev kho mob rau cov qog nqaij hlav zes qe menyuam, mob qog noj ntshav, qog nqaij hlav taub hau thiab caj dab, mob qog noj ntshav, mob qog noj ntshav, mob plab thiab cov nqaij mos sarcoma.Nyob rau hauv xyoo tas los no, los ntawm kev tshawb nrhiav tsis tu ncua ntawm cov tshuaj paclitaxel thiab kev txhim kho txuas ntxiv ntawm cov txheej txheem tsim, cov tshuaj tam sim no feem ntau suav nrog kev txhaj tshuaj paclitaxel, docetaxel (docetaxel), liposomal paclitaxel thiab albumin-bound paclitaxel.Yog li dab tsi yog qhov txawv ntawm cov tshuaj paclitaxel, cia peb kawm ntxiv txog lawv hauv qab no.
I. Qhov txawv ntawm cov haujlwm yooj yim
1. Kev txhaj tshuaj Paclitaxel: Nws yog qhia rau thawj kab thiab kev soj ntsuam ntawm kev mob qog noj ntshav ntawm zes qe menyuam, kev kho mob qog nqaij hlav qog nqaij hlav cancer mis tom qab tus txheej txheem kev kho mob ntawm adriamycin-muaj tshuaj ua ke, mob qog noj ntshav hauv cov qog nqaij hlav cancer mis uas tau ua tsis tiav kev siv tshuaj khomob ua ke lossis rov rov ua dua li ntawm 6 lub hlis ntawm kev kho tshuaj khomob ntxiv, kev kho thawj kab ntawm cov qog nqaij hlav qog nqaij hlav tsis zoo, thiab thib ob-kab kev kho mob AIDS nrog cov neeg mob carcinosarcoma.
2. Docetaxel: Rau kev kho mob qog noj ntshav siab lossis mob qog noj ntshav uas tau ua tsis tiav ua ntej kev kho mob;rau kev kho mob ntawm qib siab lossis metastatic uas tsis yog mob qog noj ntshav me me uas ua tsis tau nrog cisplatin-based chemotherapy.Nws kuj tseem siv tau rau mob qog noj ntshav plab thiab mob qog noj ntshav prostate.
3. Liposomal paclitaxel: Nws tuaj yeem siv los ua thawj kab kws khomob rau kev mob qog noj ntshav ntawm zes qe menyuam thiab thawj-kab kws khomob rau kev kho mob qog noj ntshav ntawm zes qe menyuam, thiab tseem tuaj yeem siv ua ke nrog cisplatin.Nws kuj tseem tuaj yeem siv rau kev kho mob tom qab ntawm cov neeg mob qog noj ntshav mis uas tau kho nrog cov qauv tshuaj khomob uas muaj adriamycin lossis rau kev kho mob ntawm cov neeg mob rov qab los.Nws kuj tseem tuaj yeem siv ua ke nrog cisplatin ua thawj kab kws khomob rau cov neeg mob uas tsis yog mob qog noj ntshav me me uas tsis tuaj yeem kho nrog kev phais lossis xov tooj cua.
4. Albumin-bound paclitaxel: qhia txog kev kho mob qog noj ntshav mis metastatic uas ua tsis tau cov kws khomob ua ke lossis rau kev mob qog noj ntshav ntawm lub mis uas tau tshwm sim hauv 6 lub hlis tom qab siv tshuaj kho mob ntxiv.Tshwj tsis yog muaj kev kho mob contraindications, cov kws kho mob yav dhau los yuav tsum suav nrog tus neeg sawv cev anthracycline anticancer.
II.Qhov sib txawv ntawm kev nyab xeeb tshuaj
1. Paclitaxel: dej solubility tsis zoo.Feem ntau, kev txhaj tshuaj yuav ntxiv cov surfactants polyoxyethylene-hloov cov roj castor thiab ethanol los txhim kho cov solubility ntawm paclitaxel hauv dej, tab sis histamine raug tso tawm thaum polyoxyethylene-hloov cov roj castor yog degraded hauv vivo, uas tuaj yeem ua rau muaj kev tsis haum tshuaj loj thiab tuaj yeem ua rau hnyav dua. peripheral neurotoxicity ntawm paclitaxel, thiab tseem tuaj yeem cuam tshuam qhov diffusion ntawm cov tshuaj molecules rau cov ntaub so ntswg thiab cuam tshuam cov nyhuv tiv thaiv qog.
2. Docetaxel: dej solubility tsawg, thiab nws yuav tsum tau solubilized los ntawm kev ntxiv polysorbate 80 thiab anhydrous ethanol, ob qho tib si tuaj yeem ua rau muaj qhov tshwm sim tsis zoo thiab tuaj yeem ua rau muaj kev tsis haum tshuaj thiab hemolytic.
3. Liposomal paclitaxel: cov tshuaj yog encapsulated nyob rau hauv lipid-zoo li bilayers los tsim me me vesicles, thiab cov tshuaj yog encapsulated nyob rau hauv liposomal hais yam tsis muaj polyoxyethylene-hloov castor roj thiab anhydrous ethanol, uas ua rau muaj kev tsis haum tshuaj.Txawm li cas los xij, cov kev tshawb fawb tau pom tias cov tshuaj paclitaxel nws tus kheej kuj tuaj yeem ua rau muaj kev ntxhov siab, tab sis ntawm tus nqi qis dua piv rau kev txhaj tshuaj paclitaxel.Tam sim no, paclitaxel liposomes tseem xav tau kev ua xua ua ntej kev kho mob ua ntej siv.
4. Albumin-bound paclitaxel: Ib tug tshiab paclitaxel albumin lyophilized tus neeg sawv cev siv tib neeg albumin raws li cov neeg nqa tshuaj thiab stabilizer, uas tsis muaj cov co-solvent polyoxyethylene-substituted castor roj thiab muaj ib tug kuj tsawg paclitaxel cov ntsiab lus nrog paclitaxel liposomes, thiab tsis. yuav tsum tau pretreatment ua ntej kev kho mob.
Nco tseg: Cov kev ua tau zoo thiab cov ntawv thov hauv qhov kev nthuav qhia no yog muab los ntawm cov ntaub ntawv luam tawm.
Yunnan Hande Biotechnology Co., Ltd tau tshwj xeeb hauv kev tsim khoom ntawmPaclitaxel APIrau ntau tshaj 20 xyoo, thiab yog ib lub ntiaj teb kev ywj pheej manufacturers ntawm paclitaxel API, ib tsob nroj-derived tshuaj tiv thaiv kab mob cancer, pom zoo los ntawm US FDA, European EDQM, Australian TGA, Suav CFDA, Is Nrias teb, Nyiv thiab lwm lub teb chaws cov koom haum tswj. .Hande tuaj yeem muab tsis tau zoo xwbpaclitaxel raw cov ntaub ntawv, tab sis kuj muaj kev txawj hloov cov kev pab cuam cuam tshuam nrog paclitaxel formulation.Yog xav paub ntxiv, thov hu rau peb ntawm 18187887160.
Post lub sij hawm: Dec-08-2022