Txoj kev loj hlob ntawm paclitaxel yog ib zaj dab neeg tag nrho ntawm kev sib tw thiab kev sib tw thiab kev sib tw, uas tau pib nrog kev tshawb pom ntawm cov khoom muaj nyob rau hauv taxus taxus, mus txog ntau xyoo ntawm kev tshawb fawb thiab kev loj hlob, thiab thaum kawg tau los ua ib qho tshuaj tiv thaiv kab mob hauv tsev kho mob.
Nyob rau xyoo 1960, National Cancer Institute thiab US Department of Agriculture tau koom tes nrog kev tshuaj xyuas cov nroj tsuag kom pom cov tshuaj kho mob cancer tshiab.Xyoo 1962, Barclay, tus kws kho tsiaj, tau sau cov tawv ntoo thiab nplooj los ntawm lub xeev Washington thiab xa lawv mus rau NCI kom raug kuaj rau kev tiv thaiv kabmob kheesxaws.Tom qab kev sim ntau dhau lawm, pab pawg coj los ntawm Dr. Phab ntsa thiab Dr. Wani thaum kawg cais paclitaxel hauv xyoo 1966.
Qhov kev tshawb pom ntawm paclitaxel tau nyiam dav dav thiab pib kev tshawb fawb loj thiab kev loj hlob.Hauv cov xyoo tom ntej, cov kws tshawb fawb tau tshawb fawb tob txog cov qauv tshuaj ntawm paclitaxel thiab txiav txim siab nws cov qauv molecular complex.Xyoo 1971, Dr. Wani pab pawg tau txiav txim siab ntxiv cov qauv siv lead ua thiab NMR spectroscopy ntawmpaclitaxel, tso lub hauv paus rau nws daim ntawv thov kev kho mob.
Paclitaxel tau ua tau zoo hauv kev sim tshuaj thiab tau dhau los ua thawj kab kev kho mob qog noj ntshav ntawm lub mis thiab zes qe menyuam thiab qee lub taub hau, caj dab thiab mob ntsws.Txawm li cas los xij, cov peev txheej ntawm paclitaxel tsawg heev, uas txwv nws txoj kev kho mob dav dav.Yuav kom daws tau qhov teeb meem no, cov kws tshawb fawb tau ua ntau txoj kev tshawb fawb los tshawb nrhiav cov synthesis ntawm paclitaxel.Tom qab ntau xyoo ntawm kev siv zog, tib neeg tau tsim ntau txoj hauv kev los ua ke paclitaxel, suav nrog tag nrho cov synthesis thiab semi-synthesis.
Nyob rau hauv lub neej yav tom ntej, kev tshawb fawb ntawmpaclitaxelyuav nyob rau hauv-tob.Nrog rau kev nce qib ntawm kev tshawb fawb thiab thev naus laus zis, tib neeg yuav tsum pom ntau cov tshuaj bioactive cuam tshuam nrog paclitaxel thiab nkag siab ntxiv txog nws txoj kev ua haujlwm.Nyob rau tib lub sijhawm, nrog kev txhim kho txuas ntxiv ntawm cov cuab yeej siv hluav taws xob sib txuas, kev sib txuas ntawm paclitaxel yuav ua tau zoo dua thiab zoo ib puag ncig, thiaj li muab kev lees paub zoo dua rau nws daim ntawv thov kev kho mob dav.Tsis tas li ntawd, cov kws tshawb fawb tseem yuav tshawb nrhiav kev siv paclitaxel nrog rau lwm cov tshuaj tiv thaiv kab mob los muab kev kho mob zoo dua.
Hauv luv luv,paclitaxelyog ib qho tshuaj tiv thaiv kab mob ntuj nrog cov txiaj ntsig tseem ceeb, thiab nws txoj kev tshawb fawb thiab kev txhim kho yog tag nrho ntawm cov teeb meem thiab kev ua tiav.Nyob rau hauv lub neej yav tom ntej, nrog kev nce qib ntawm kev tshawb fawb thiab thev naus laus zis thiab kev tshawb fawb tob, paclitaxel yuav tsum ua lub luag haujlwm tseem ceeb hauv kev kho mob ntau hom qog noj ntshav.
Nco tseg: Cov txiaj ntsig zoo thiab cov ntawv thov uas tau nthuav tawm hauv kab lus no yog muab los ntawm cov ntaub ntawv luam tawm.
Post lub sij hawm: Nov-13-2023