Paclitaxel yog ib yam khoom ntuj tsim tawm los ntawm cov tawv ntoo ntawm tsob ntoo Pacific yew (Taxus pacifica).Lub biosynthesis ntawm paclitaxel cuam tshuam txoj kev biosynthetic complex, nrog rau ntau yam enzymes thiab intermediates.Txawm hais tias txoj kev ua tiav rau kev sib txuas ntawm paclitaxel tau kawm, nws tseem nyob. Kev nyuaj hauv kev tsim khoom tiag tiag.Ntawm no yog cov ntsiab lus dav dav ntawm paclitaxel biosynthesis:
1.Cov khoom pib: Lub biosynthesis ntawm paclitaxel pib nrog cov khoom pib ntuj, feem ntau yog los ntawm nplooj lossis tawv ntoo ntawm tsob ntoo yew.Cov khoom pib no muaj cov niam txiv sib txuas uas tuaj yeem siv los ua cov paclitaxel lub precursors.
2.Multi-enzyme catalysis: Biosynthesis ntawmpaclitaxelYuav tsum muaj ntau yam enzymes los catalyze cov tshuaj tiv thaiv.Cov enzymes hloov cov tshuaj pib mus rau hauv nruab nrab uas nce zuj zus tuaj yeem ua rau paclitaxel's precursor molecules.
3.Synthesis ntawm intermediates: Intermediates yog ib kauj ruam tseem ceeb nyob rau hauv lub synthesis ntawm paclitaxel.Lawv muaj polycyclic tebchaw thiab sab saw lug uas yog synthesized maj mam los ntawm ib tug series ntawm enzyme-catalyzed tshua.
4.Qhov kawg synthesis ntawm paclitaxel: Lub precursor molecules rau lub synthesis ntawm paclitaxel yog maj synthesis rau paclitaxel molecules nyob rau hauv ntau yam tshuaj tiv thaiv theem.Cov tshuaj no muaj xws li polycyclic synthesis, acylation, deketone, thiab lwm yam tseem ceeb cov kauj ruam.
5.Extraction thiab purification: Tom qab lub synthesis ntawm paclitaxel, ib tug extraction thiab purification kauj ruam yuav tsum tau cais cov ntshiab paclitaxel los ntawm cov tshuaj tiv thaiv sib tov.
Txawm hais tias ntuj biosynthetic txoj kev ntawmpaclitaxeltau kawm, qhov tseeb zus tau tej cov paclitaxel tseem nyuaj vim hais tias nws yuav tsum tau complex synthesis nrog ntau cov kauj ruam thiab loj npaum li cas ntawm raw cov ntaub ntawv.Vim cov kev cov nyom, cov kws tshawb fawb kuj tau tshawb xyuas cov txheej txheem hluavtaws los synthesize paclitaxel nyob rau hauv thiaj li yuav ua rau kom nws yield thiab muaj.Synthetic synthesis ntawm paclitaxel feem ntau yog ib txoj kev yooj yim dua synthesis los txo qhov nyuaj.
Nco tseg: Cov txiaj ntsig zoo thiab cov ntawv thov tau nthuav tawm hauv kab lus no yog muab los ntawm cov ntaub ntawv luam tawm.
Yunnan Hande Biotechnology Co., Ltd. tau teem rau zus tau tej cov paclitaxel rau 26 xyoo, thiab yog ib tug ywj siab chaw tsim tshuaj paus ntawm tsob nroj-extracted anti-cancer tshuaj paclitaxel API pom zoo los ntawm lub tebchaws United States FDA, Teb chaws Europe EDQM, Australia TGA, Tuam Tshoj CFDA , Is Nrias teb, Nyiv thiab lwm lub teb chaws cov koom haum tswj hwm.Yunnan Hande paclitaxel, chaw muab khoom, Hoobkas ncaj muag muag, txais tos nug, 18187887160 (WhatsApp tib tus lej)
Post lub sij hawm: Oct-12-2023