Paclitaxel yog ib yam khoom uas muab rho tawm los ntawm yew, uas tuaj yeem cuam tshuam kev mob qog noj ntshav thiab yog cov tshuaj tiv thaiv kab mob hauv ntiaj teb tau siv dav hauv xyoo 1960, American chemists cais taxol los ntawm cov tawv ntoo ntawm Pacific yew, Taxus tsob nroj.Thiab ntau tshaj 20 xyoo. Kev tshawb fawb soj ntsuam, thawj qhov kev txhaj tshuaj paclitaxel "Taxol" tau tsim tawm xyoo 1992. Txog tam sim no,paclitaxelNws muaj cov yam ntxwv ntawm kev ua haujlwm siab, tsis muaj tshuaj lom thiab dav dav. mob qog noj ntshav thiab mob qog noj ntshav.
Cov txiaj ntsig ntawm kev sim tshuaj kho mob qhia tau tias, tam sim no, qhov tau los ntawmPaclitaxel APIsFeem ntau yog nyob ntawm kev rho tawm ntawm Taxus chinensis cov nroj tsuag thiab tshuaj Semisynthesis.Cov kws tshawb fawb tshawb fawb sau cov ntoo cog qoob loo thiab nplooj ntawm Taxus chinensis chinensis, siv cov kuab tshuaj extraction, cov theem khoom extraction, supercritical kua extraction, kev sib cais ntawm cov membrane, chromatographic sib cais thiab lwm yam kev sib cais thiab extraction txoj kev. extract precursors zoo ib yam li cov qauv ntawm paclitaxel, xws li bacatine III, 10 deacetyl bacatine III, thiab lwm yam., thiab tom qab ntawd tau txais kev kho mob paclitaxel bulk tshuaj los ntawm kev hloov kho tshuaj ntawm cov txheej txheem ntau lawm.
Raws li cov kws tshawb fawb suav, cov neeg mob qog noj ntshav yuav tsum tau noj ntau dua 2 gramspaclitaxelnyob rau hauv ib qho kev kho mob ib leeg.Cov kab ntawm paclitaxel yuav tsum tau muab rho tawm los ntawm cov tawv ntoo ntawm 4-8 qus Taxus chinensis ntoo uas tau loj hlob rau ntau tshaj 50 xyoo. Ntawm ib sab tes, Taxus chinensis thiab paclitaxel tsis tshua muaj, thiab ntawm qhov lwm yam tes, muaj kev xav tau kev kho mob loj heev, uas ua rau tus nqi siab ntawm Taxus chinensis raw khoom txhua xyoo puag ncig, thiab cov khoom poob qis ntawm kev thov.
Kev piav qhia: Lub peev xwm ua tau zoo thiab cov ntawv thov tau hais hauv kab lus no yog tag nrho los ntawm cov ntaub ntawv muaj nyob rau pej xeem.
Kev nyeem ntawv txuas ntxiv: Yunnan Hande Bio-tech feem ntau koom nrog kev rho tawm thiab txhim kho taxanes.Nws cov khoom tseem ceeb yog Paclitaxel, 10-DAB Semisynthesis Paclitaxel, 10-DABIII, docetaxel, cabataxel, thiab lwm yam Yog tias koj xav paub txog paclitaxel raws li raw cov ntaub ntawv, thov koj xav tiv tauj peb ntawm.
Post lub sij hawm: Jun-14-2023