Paclitaxel tiv thaiv qog noj ntshav li cas?

Paclitaxel yog ib qho diterpenoid muab rho tawm los ntawm Taxus genus Taxus, thiab cov kws tshawb fawb tau pom tias nws muaj zog tiv thaiv kab mob hauv kev sim tshuaj ntsuam.Tam sim no,paclitaxelyog dav siv nyob rau hauv kev kho mob cancer ntawm lub mis, qog noj ntshav ntawm zes qe menyuam, uas tsis yog-hlwb cell ntsws cancer, pancreatic cancer, esophageal cancer, gastric cancer, lub taub hau thiab caj dab hlav, cov nqaij mos sarcoma thiab lwm yam malignant qog, thiab nws yog ib qho ntawm feem ntau nquag. siv cov tshuaj chemotherapy hauv kev kho mob.Yog li cas raws nraim li paclitaxel tiv thaiv qog noj ntshav?Cia peb saib hauv qab no.

Paclitaxel tiv thaiv qog noj ntshav li cas?Nws yog paub zoo tias thaum lub sij hawm ib txwm cell faib, lub cell muab faib ua ob feem.Tom qab cov chromosome replicated, lub spindle filament rub nws los ntawm nws thawj txoj hauj lwm mus rau ob sab, thiab spindle xav tau lub depolymerization ntawm microtubules raws li lub cytoskeleton rau daim ntawv, Chromosomes tsuas tuaj yeem ua tiav mitosis los ntawm kev txav mus rau cov ncej hauv qab traction ntawm spindle thiab spindle filament, yog li microtubules tseem ceeb heev hauv kev faib cell.

Xyoo 1979, tus kws kho mob Horwitz tau tshawb pom qhov ntawdpaclitaxeltuaj yeem khi rau tubulin thiab txhawb cov polymerization ntawm tubulin los ua microtubules, yog li inhibiting lub cev tsis sib haum xeeb ntawm microtubules, ua rau nws tsis tuaj yeem tsim cov spindles thiab spindle filaments, ua rau cov hlwb tsis muaj peev xwm faib tau ib txwm tiv thaiv kev loj hlob sai ntawm cov qog nqaij hlav thiab induces apoptosis. ntawm cov qog nqaij hlav cancer.Yog li, ntawm cov tshuaj tiv thaiv kab mob, paclitaxel suav tias yog microtubule inhibitor hauv mitosis.

Nco tseg: Cov kev ua tau zoo thiab kev siv tau piav qhia hauv kab lus no yog muab los ntawm cov ntaub ntawv luam tawm.

Kev nyeem ntawv txuas ntxiv:Yunnan Hande Biotechnology Co., Ltd. tau tsom mus rau kev tsim cov paclitaxel rau 28 xyoo.Nws yog lub ntiaj teb thawj tus neeg ua haujlwm ywj pheej ntawm cov nroj tsuag-derived anticancer tshuaj paclitaxel uas tau pom zoo los ntawm US FDA, European EDQM, Australian TGA, Tuam Tshoj CFDA, Is Nrias teb, Nyiv thiab lwm lub tebchaws tswj hwm.kev lag luam.Yog xav yuavPaclitaxel API,thov hu rau peb hauv online.