Paclitaxel yog ib qho tseem ceeb ntawm cov tshuaj tiv thaiv kab mob, thiab nws cov qauv tshwj xeeb thiab kev ua haujlwm lom neeg tau nyiam ntau yam los ntawm cov kws tshawb fawb.Raws li nws qhov chaw thiab kev npaj, paclitaxel tuaj yeem muab faib ua ntuj paclitaxel thiab semi-synthetic paclitaxel.Cov kab lus no yuav tham txog qhov sib txawv thiab qhov zoo. ntawm ob.
Qhov chaw thiab txheej txheem npaj
Ntuj paclitaxel:Natural paclitaxel feem ntau yog muab rho tawm los ntawm Pacific yew ntoo (Taxus brevifolia).No tsob ntoo no yog nplua nuj nyob rau hauv paclitaxel, tab sis nyob rau hauv tsawg kom muaj nuj nqis, ua rau cov khoom ntawm ntuj paclitaxel kuj scarce.
Semi-synthetic paclitaxel: Semi-synthetic paclitaxel yog tsim los ntawm cov tshuaj synthesis los ntawm taxanes muab rho tawm los ntawm cov tawv ntoo ntawm taxus chinensis.Qhov no tuaj yeem siv los tsim paclitaxel ntawm cov nplai loj kom tau raws li kev kho mob.
Cov qauv tshuaj
Txawm hais tias ntuj paclitaxel thiab semi-synthetic paclitaxel txawv me ntsis hauv cov qauv tshuaj, lawv cov qauv tseem ceeb yog tib yam, thiab ob qho tib si yog diterpenoid alkaloids.Cov qauv tshwj xeeb no ua rau lawv muaj kev lom zem ntau.
Kev ua haujlwm lom neeg thiab kev ua tau zoo
Ntuj paclitaxel: Hauv kev xyaum kho mob, ntuj paclitaxel tau pom tias muaj kev kho mob tseem ceeb ntawm ntau yam qog nqaij hlav, nrog rau mob qog noj ntshav, qog nqaij hlav hauv zes qe menyuam, qee cov qog nqaij hlav taub hau thiab caj dab, thiab mob ntsws cancer. ntawm tubulin thiab rhuav tshem cov cell microtubule network, yog li inhibiting cell proliferation thiab inducing apoptosis ntawm cov qog nqaij hlav cancer.
Semi-synthetic paclitaxel: Semi-synthetic paclitaxel zoo sib xws hauv kev ua tau zoo rau ntuj paclitaxel thiab tseem muaj cov haujlwm tseem ceeb hauv kev tiv thaiv qog noj ntshav.Mass ntau lawm ntawm semi-synthetic paclitaxel tuaj yeem ua rau cov khoom siv kho mob thiab muab ntau txoj kev kho mob rau cov neeg mob qog noj ntshav.
Toxic phiv
Ntuj paclitaxel: Cov tshuaj toxicity ntawm ntuj paclitaxel kuj tsis tshua muaj, tab sis nws tseem yuav ua rau muaj qee yam tsis zoo, xws li kev ua xua, pob txha pob txha thiab mob toxicity.
Semi-synthetic paclitaxel: Cov kev mob tshwm sim ntawm semi-synthetic paclitaxel zoo ib yam li cov paclitaxel ntuj.Ob leeg yuav tsum tau noj tshuaj raws li tus neeg mob thiab cov kws kho mob cov lus pom zoo kom txo tau qhov kev pheej hmoo ntawm kev phiv tshuaj.
Kev txhim kho yav tom ntej Prospects
Nrog rau kev nce qib ntawm kev tshawb fawb thiab thev naus laus zis, kev tshawb fawb ntawm paclitaxel kuj tseem tob zuj zus.Nyob rau hauv lub neej yav tom ntej, cov kws tshawb fawb yuav ua hauj lwm los nrhiav cov txheej txheem zoo dua ntawm paclitaxel synthesis los txhim kho nws cov txheej txheem ntau lawm thiab txhim kho kev kho mob. kev txhim kho cov thev naus laus zis tshiab xws li genetic engineering thiab cell therapy, cov tswv yim kho tus kheej rau paclitaxel kuj tseem tuaj yeem ua tau, yog li muab cov neeg mob qog noj ntshav nrog kev kho mob zoo dua thiab muaj txiaj ntsig zoo.
Xaus
Ob leegntuj paclitaxelthiabsemi-synthetic paclitaxelTxawm hais tias lawv cov keeb kwm thiab kev npaj cov txheej txheem sib txawv, lawv muaj qhov sib xws hauv cov qauv tshuaj, kev ua haujlwm lom neeg thiab cov tshuaj pharmacodynamics.Qhov loj-loj ntau lawm ntawm semi-synthetic paclitaxel tuaj yeem ua rau cov khoom siv kho mob, thaum ntuj paclitaxel muaj ib Nyob rau hauv kev tshawb fawb yav tom ntej, cov kws tshawb fawb yuav txuas ntxiv tshawb nrhiav cov txheej txheem lom neeg ntawm kev ua thiab kev siv thaj chaw ntawm paclitaxel kom coj kev cia siab ntau ntxiv rau cov neeg mob qog noj ntshav.
Nco tseg: Cov txiaj ntsig zoo thiab cov ntawv thov tau nthuav tawm hauv kab lus no yog muab los ntawm cov ntaub ntawv luam tawm.
Post lub sij hawm: Nov-29-2023