Paclitaxel (Paclitaxel) yog cov tshuaj tua kab mob ntuj tsim tawm los ntawm cov nroj tsuag yew, uas muaj cov qauv tshuaj lom neeg thiab cov tshuaj siv tshuaj.Txij li thaum nrhiav pom paclitaxel hauv xyoo 1971, nws daim ntawv thov kev kho mob tau ua tiav cov txiaj ntsig zoo kawg li.Nyob rau hauv daim ntawv no, cov qauv tshuaj thiab pharmacological kev txiav txim ntawmpaclitaxelyuav tau tham.
Cov qauv tshuaj ntawm paclitaxel
Cov qauv tshuaj ntawm paclitaxel yog complex, muaj ntau lub nplhaib qauv, nrog rau ib tug core diterpenoid qauv, uas yog ib feem tseem ceeb ntawm cov anti-cancer nyhuv ntawm paclitaxel.Paclitaxel molecules kuj muaj ib tug xov tooj ntawm hydroxyl thiab ketone pawg, thiab qhov chaw thiab tus naj npawb ntawm cov pab pawg neeg txiav txim nws tshwj xeeb pharmacological kev ua.
Cov teebmeem pharmacological ntawm paclitaxel
1. Microtubule stabilization: Paclitaxel tuaj yeem txhawb cov polymerization ntawm microtubules thiab stabilize cov polymerized microtubules, uas yog ib qho tseem ceeb mechanism ntawm nws anticancer nyhuv.Microtubules ua lub luag haujlwm tseem ceeb hauv kev faib cell, thiab paclitaxel inhibits qog kev loj hlob los ntawm stabilizing microtubules thiab tiv thaiv cell division.
2, induce cell voj voog ntes: paclitaxel tuaj yeem ua rau lub voj voog ntawm tes raug ntes, kom cov hlwb tsis tuaj yeem txuas ntxiv mus rau kev faib thiab loj hlob.Qhov no yog lwm yam tseem ceeb ntawm nws cov nyhuv anticancer.
3, induce apoptosis: paclitaxel tuaj yeem ua rau kev nthuav tawm ntawm ntau tus neeg sib tw pro-apoptosis, ua kom cov txheej txheem apoptosis ntawm cov qog nqaij hlav cancer.
4, kev tswj hwm ntawm cov tshuaj tiv thaiv apoptotic: paclitaxel kuj tseem tuaj yeem tswj cov kev ua haujlwm ntawm cov tshuaj tiv thaiv apoptotic kom sib npaug ntawm cov txheej txheem ntawm apoptosis thiab kev loj hlob.
Xaus
Paclitaxel yog ib hom tshuaj tiv thaiv kabmob kheesxaws uas muaj cov qauv tshuaj lom neeg thiab cov tshuaj siv tshuaj.Nws tuaj yeem cuam tshuam cov qog loj hlob los ntawm kev txhawb nqa microtubule polymerization, stabilizing polymerized microtubules, inducing cell voj voog ntes thiab inducing cell apoptosis.Txawm li cas los xij, toxicity thiab kev phiv ntawm paclitaxel kuj yog ib qho kev txhawj xeeb hauv kev siv tshuaj kho mob.Kev tshawb fawb ntxiv thiab kev nkag siab txog cov tshuaj pharmacological ntawm paclitaxel yuav pab txhim kho nws txoj kev siv tshuaj kho mob, txhim kho cov txiaj ntsig kho mob, thiab txo cov kev mob tshwm sim.
Yav tom ntej Outlook
Txawm hais tias daim ntawv thov kev kho mob ntawm paclitaxel tau ua tiav cov txiaj ntsig zoo, qhov teeb meem ntawm nws cov peev txheej tsawg thiab cov khoom siv nruj tseem muaj.Yog li ntawd, cov kws tshawb fawb hauv thaj chaw ntawm hluavtaws biology thiab tshuaj chemistry tau ua haujlwm los nrhiav lwm txoj hauv kev rau paclitaxel los daws nws cov teeb meem khoom siv thiab txo cov nqi tsim khoom.Tsis tas li ntawd, kev tshawb fawb txog cov tshuaj pharmacological ntawmpaclitaxeltseem yuav pab kom nrhiav tau cov tswv yim kho mob zoo dua los daws ntau yam mob qog noj ntshav.
Hauv kev tshawb fawb preclinical thiab kev sim tshuaj, kev sib xyaw ntawm paclitaxel thiab lwm yam tshuaj tiv thaiv kab mob tau pom tias muaj kev cia siab.Los ntawm kev sib txuas ntawm paclitaxel nrog lwm cov tshuaj, kev kho mob tuaj yeem txhim kho thiab qhov tshwm sim ntawm kev tsis kam txo.Nyob rau hauv lub neej yav tom ntej, nrog rau qhov nrov ntawm cov tshuaj precision thiab cov tswv yim kho tus kheej, kev tshawb fawb thiab kev nkag siab ntawm cov tshuaj pharmacological ntawm paclitaxel yuav ua kom tob dua, thiab cov kev kho kom raug thiab zoo dua yuav muab rau cov neeg mob qog noj ntshav.
Feem ntau, paclitaxel yog cov tshuaj tiv thaiv kab mob ntuj tsim nrog cov qauv tshuaj lom neeg thiab cov tshuaj pharmacological.Nrog kev nce qib ntawm kev tshawb fawb thiab thev naus laus zis thiab kev tshawb fawb tob tob, peb tos ntsoov raupaclitaxelua lub luag haujlwm ntau dua hauv kev kho mob qog noj ntshav rau yav tom ntej, nqa cov txiaj ntsig kev kho mob zoo dua thiab lub neej zoo rau cov neeg mob.
Nco tseg: Cov txiaj ntsig zoo thiab cov ntawv thov uas tau nthuav tawm hauv kab lus no yog muab los ntawm cov ntaub ntawv luam tawm.
Post lub sij hawm: Nov-15-2023