Cov ntaub ntawv khoom
Artemisinin yog ib yam tshuaj uas muaj txiaj ntsig zoo tshaj plaws hauv kev kho mob malaria.Nws yog sesquiterpene lactone nrog peroxide pawg muab rho tawm los ntawm Artemisia annua.Nws muaj cov yam ntxwv ntawm kev ua haujlwm siab, ua haujlwm sai, tshem tawm cov cua sov thiab txo cov cua sov thaum lub caij ntuj sov, txo qis cua sov, tua protozoa thiab tsis muaj tshuaj lom.Tam sim no, kev ua tau zoo ntawm artemisinin raws li kev kho mob ua ke (ACT) rau kev kho mob malaria tau mus txog ntau dua 90% thoob plaws ntiaj teb.Nws tau siv dav hauv kev kho mob malaria thoob plaws ntiaj teb.
1 、 Muaj nuj nqi
1. Tshuaj tiv thaiv malaria
Malaria (feem ntau hu ua pendulum cold and fever disease) yog kab mob kis kab mob.Nws yog tus kab mob kis tau los ntawm qhov tom ntawm tib neeg lub cev kis los ntawm Plasmodium.Nws tuaj yeem tshwm sim hepatosplenomegaly thiab anemia tom qab rov ua dua rau lub sijhawm ntev.Artemisinin tau pab txhawb kev kho mob malaria rau qee yam.Lub peroxide daim ntawv cog lus nyob rau hauv cov qauv ntawm artemisinin yog oxidizing thiab yog ib pab pawg tseem ceeb rau malaria kuj.Cov txheej txheem ntawm kev ua yog tias cov pab pawg dawb tsim los ntawm artemisinin hauv vivo khi rau Plasmodium falciparum protein thiab hloov cov cell membrane qauv ntawm Plasmodium falciparum.Tom qab cov dawb radicals ua ke nrog Plasmodium protein, lub bilayer daim nyias nyias ntawm mitochondria yuav o thiab tawg, thiab thaum kawg poob tawm, ua rau kev puas tsuaj ntawm cov qauv ntawm tes thiab kev ua haujlwm ntawm Plasmodium, thiab cov chromatin nyob rau hauv lub nucleus kuj yuav cuam tshuam rau qee qhov. qhov twg.
2. Antitumor
Malignant qog yog thawj tus neeg tua neeg ua rau tib neeg noj qab haus huv.Yog tias tsis kho raws sijhawm, nws yuav ua rau muaj kev phom sij rau lub neej.Kev sim hauv vitro tau pom tias qee qhov koob tshuaj artemisinin tuaj yeem ua rau apoptosis ntawm ntau hom qog noj ntshav, xws li hepatoma hlwb, qog nqaij hlav cancer mis, qog nqaij hlav qog noj ntshav thiab lwm yam, thiab cuam tshuam kev loj hlob ntawm cov qog nqaij hlav cancer.Nws tau pom tias artemisinin tuaj yeem tswj cov kev qhia ntawm cyclin hauv cov qog hlwb, txhim kho cov nyhuv ntawm CKIs thiab ua rau qog cell voj voog raug ntes;Los yog ua rau apoptosis thiab inhibit qog angiogenesis los tiv thaiv qhov tshwm sim thiab kev loj hlob ntawm qog.Artemisinin yog siv los kho cov kab mob leukemia los ntawm kev ua haujlwm ntawm cov cell membrane ntawm leukemia hlwb, nce permeability ntawm daim nyias nyias thiab hloov osmotic siab, uas ua rau kom cov calcium concentration nyob rau hauv lub hlwb, thiaj li mus qhib calpain, ua rau nws cell membrane o. thiab tawg, nrawm tso tawm cov tshuaj apoptotic thiab ua kom nrawm ntawm apoptosis.
3. Kev kho mob ntsws pulmonary hypertension
Pulmonary hypertension (PAH) yog lub xeev pathophysiological yam ntxwv los ntawm pulmonary artery remodeling thiab nce siab ntawm pulmonary hlab ntsha mus rau ib qho kev txwv.Nws tuaj yeem yog ib qho teeb meem los yog syndrome.Artemisinin yog siv los kho pulmonary hypertension: nws tuaj yeem txo cov hlab ntsha pulmonary siab thiab txhim kho cov tsos mob ntawm cov neeg mob PAH los ntawm kev so cov hlab ntsha.Zaim et al.Pom tau tias artemisinin muaj cov nyhuv anti-inflammatory.Artemisinin thiab nws cov ntsiab lus tseem ceeb tuaj yeem cuam tshuam ntau yam inflammatory yam, thiab tseem tuaj yeem inhibit qhov tsim ntawm nitric oxide los ntawm inflammatory mediators;Artemisinin muaj cov nyhuv immunomodulatory;Feng Yibai thiab lwm tus pom tias artemisinin tuaj yeem tiv thaiv kev loj hlob ntawm vascular endothelial hlwb thiab vascular du leeg hlwb, thiab tom qab ntawd ua lub luag haujlwm tseem ceeb hauv kev kho PAH;Artemisinin tuaj yeem cuam tshuam kev ua haujlwm ntawm matrix metalloproteinases, yog li inhibiting pulmonary vascular remodeling;Artemisinin tuaj yeem cuam tshuam qhov kev qhia ntawm PAH ntsig txog cytokines thiab ntxiv dag zog rau kev tiv thaiv vascular remodeling nyhuv ntawm artemisinin.
4. Kev tiv thaiv kab mob
Nws tau pom tias ntau npaum li cas ntawm artemisinin thiab nws cov derivatives tuaj yeem cuam tshuam T lymphocyte mitogen zoo dua thiab ua rau muaj kev loj hlob ntawm nas spleen lymphocytes yam tsis muaj cytotoxicity.Qhov kev tshawb pom no muaj txiaj ntsig zoo rau kev kho mob ntawm T lymphocyte mediated autoimmune kab mob.Artemisia annua iav vinegar tuaj yeem txhim kho kev tiv thaiv tsis muaj zog thiab txhim kho tag nrho cov haujlwm ntxiv ntawm nas cov ntshav.Dihydroartemisinin tuaj yeem cuam tshuam ncaj qha rau kev loj hlob ntawm B lymphocytes, txo qis kev tso tawm ntawm autoantibodies los ntawm B lymphocytes, txo qis kev tiv thaiv kab mob humoral, inhibit humoral tiv thaiv kab mob thiab txo qhov tsim ntawm kev tiv thaiv kab mob.
5. Antifungal
Cov nyhuv antifungal ntawm artemisinin kuj ua rau artemisinin qhia qee yam tshuaj tua kab mob.Cov kev tshawb fawb tau lees paub tias cov hmoov seem thiab dej decoction ntawm artemisinin muaj cov tshuaj tua kab mob muaj zog ntawm anthrax, Staphylococcus epidermidis, catarrhalis thiab diphtheria, thiab tseem muaj qee yam tshuaj tua kab mob rau tuberculosis, Pseudomonas aeruginosa, Staphylococcus aureus thiab dysentery bacill.
2 、 Daim ntawv thov teb
Artemisia annua yog siv los ua tshuaj tiv thaiv kab mob.Nws daim ntawv thov kev kho mob tau ua pov thawj tias artemisinin thiab nws cov derivatives muaj cov teebmeem tshwj xeeb ntawm Plasmodium falciparum thiab Plasmodium falciparum, tshwj xeeb tshaj yog Artemisia annua a, uas muaj cov nyhuv muaj zog dua li lwm cov tshuaj artemisinin ntawm kev tua cov intracellular clones ntawm Plasmodium falciparum.
Khoom Parameters
| COMPANY PROFILE | |
| Khoom npe | Artemisinin ua |
| CAS | 63968-64-9 |
| Tshuaj Formula | C15H22O5 |
| Brand | Hande ua |
| Mtus tsim khoom | YUnnan Hande Bio-Tech Co., Ltd. |
| Cuntry | Kunming,China |
| Tsim los | 1ib 993 |
| BASIC INFORMATION | |
| Synonyms | 3,12-epoxy-12h-pyranol(4,3-j)-1,2-benzodioxepin-10(3h)-ib, octahydro-3,6,9-tri;artemisianannual., rho tawm; huanghuahaosu;octahydro-3,6,9-trimethyl-3,12-epoxy-12h-pyrano(4,3-j)-1,2-benzodioxepin-10(;qinghausau;qinghausu; QHS; ARTEMISININ 99% |
| Qauv |  |
| Qhov hnyav | 282.34 ib |
| HS Code | N/A |
| ZooSpecification | Tuam txhab Specification |
| Cua pov thawj | N/A |
| Assay | Customized raws li cov neeg siv khoom xav tau |
| Qhov tshwm sim | Tsis muaj xim acicular crystal |
| Txoj kev Extraction | Artemisia xyoo |
| Muaj peev xwm txhua xyoo | Customized raws li cov neeg siv khoom xav tau |
| Pob | Customized raws li cov neeg siv khoom xav tau |
| Txoj Kev Xeem | N/A |
| Logistics | Ntauthaujs |
| Pkev aymentTua erms | T / T, D / P, D / A |
| Omuaj | Txais cov neeg siv khoom tshawb xyuas txhua lub sijhawm;Pab cov neeg muas zaub nrog kev cai sau npe. |
Hande cov lus qhia khoom
1.Tag nrho cov khoom muag los ntawm lub tuam txhab yog semi-tiav raw khoom.Cov khoom lag luam yog tsom rau cov tuam txhab tsim khoom tsim nyog, thiab cov khoom siv raw tsis yog cov khoom kawg.
2.Qhov muaj peev xwm ua tau zoo thiab cov ntawv thov koom nrog hauv kev taw qhia yog tag nrho los ntawm cov ntaub ntawv luam tawm.Cov tib neeg tsis pom zoo kom siv ncaj qha, thiab cov neeg yuav khoom raug tsis kam lees.
3.Cov duab thiab cov ntaub ntawv khoom ntawm lub vev xaib no yog siv rau kev siv xwb, thiab cov khoom tiag tiag yuav yeej.
