Paclitaxel yog ib qho tshuaj zoo tshaj plaws los tiv thaiv kab mob qog noj ntshav uas tau pom nyob rau tam sim no.Nws yog dav siv hauv kev kho mob ntawm zes qe menyuam qog noj ntshav, mob qog noj ntshav mis, mob qog noj ntshav, qog nqaij hlav taub hau thiab caj dab, mob qog noj ntshav, mob plab, mob plab thiab cov nqaij mos sarcoma.Paclitaxeltau txais kev txaus siab zoo los ntawm cov kws tshawb fawb vim nws cov qauv tshuaj lom neeg thiab cov qauv tshiab, cov txheej txheem lom neeg lom zem ntawm kev ua haujlwm, kev ua haujlwm tiv thaiv kab mob, thiab cov peev txheej tsis txaus. synthesis ntawm paclitaxel, thiab kev sib tw yog nruj heev, uas tau dhau los ua qhov tseem ceeb ntawm cov organic synthetic chemistry nyob rau hauv lub xyoo pua 20th.
Cov tshuaj tiv thaiv qog nqaij hlav tshwj xeeb ntawm paclitaxel
Paclitaxel tuaj yeem ua rau Tubulin thiab Tubulin dimer uas ua rau microtubules poob Dynamic equilibrium, induce thiab txhawb Tubulin polymerization, microtubule los ua ke, thiab tiv thaiv depolymerization, thiaj li stabilize microtubules thiab inhibit Mitosis ntawm cov qog nqaij hlav qog noj ntshav thiab ua rau apoptosis, yog li tiv thaiv kev loj hlob ntawm cov qog nqaij hlav cancer. cov hlwb thiab ua si lub luag haujlwm tiv thaiv qog noj ntshav.
Qhov tseeb, Tubulin, uas yog ze ze rau ntawm tes Mitosis, muaj yuav luag universally nyob rau hauv tag nrho cov eukaryotic hlwb.Lawv muaj peev xwm polymerize rau hauv microtubules reversibly.Chromosome sib cais yuav tsum tau kev pab los ntawm cov microtubules.Tom qab Mitosis, cov microtubules yog dua depolymerized rau hauv Tubulin. Disintegration ntawm rauj zoo li microtubules tuaj yeem nyiam tua cov hlwb nrog kev faib tawm txawv txav. Qee cov tshuaj tiv thaiv kabmob tseem ceeb, xws li colchicine, Vinblastine, Vincristine, ua lub luag haujlwm tiv thaiv qog los ntawm kev tiv thaiv Tubulin los ntawm re polymerization.
Contrary to anti Mitosis thiab tshuaj tiv thaiv qog,paclitaxelyog thawj cov tshuaj pom tau tias tuaj yeem cuam tshuam nrog Tubulin polymer, uas yog, nws ua haujlwm los ntawm kev sib txuas nrog microtubules kom lawv ruaj khov.Tam sim no, nws pom tias paclitaxel qhia tau hais tias muaj txiaj ntsig zoo rau ntau hom qog nqaij hlav. Kev tshawb pom tau nyiam ntau tus kws tshawb fawb biologist sivpaclitaxelraws li cov cuab yeej tshawb fawb hauv biomedicine, tshawb nrhiav thaj chaw tsis paub txog kev ua haujlwm ntawm tes thiab nrhiav pom txoj hauv kev tshiab rau cov tshuaj tiv thaiv kab mob.
Kev piav qhia: Lub peev xwm ua tau zoo thiab cov ntawv thov tau hais hauv kab lus no yog tag nrho los ntawm cov ntaub ntawv muaj nyob rau pej xeem.
Yunnan Hande Bio-tech tau tsom mus rau kev tsim cov paclitaxel rau 28 xyoo.Nws yog kev lag luam ywj pheej ntawm cov khoom siv paclitaxel, uas tau pom zoo los ntawm cov koom haum tswj hwm hauv tebchaws xws li FDA hauv Tebchaws Meskas, EDQM hauv Tebchaws Europe, TGA hauv Australia, CFDA hauv Suav teb, Is Nrias teb, thiab Nyiv.Yunnan Hawmpaclitaxelmuaj nyob rau hauv Tshuag thiab muag ncaj qha los ntawm manufacturers.Txais tos nug.
Post lub sij hawm: Jun-12-2023