Paclitaxel, tshuaj tiv thaiv kab mob ntuj tsim nrog cov mis C47H51NO14, tau siv dav hauv kev kho mob qog noj ntshav mis, qog noj ntshav ntawm zes qe menyuam thiab qee lub taub hau, caj dab thiab mob qog noj ntshav.Raws li ib tug diterpenoid alkaloid nrog anticancer kev ua,paclitaxeltau txais txiaj ntsig zoo los ntawm botanists, chemists, pharmacologists thiab molecular biologists vim nws cov qauv tshiab thiab cov tshuaj lom neeg, kev ua haujlwm loj thiab tseem ceeb ntawm cov roj ntsha, cov txheej txheem tshiab thiab tshwj xeeb ntawm kev ua, thiab tsis tshua muaj peev txheej, ua rau nws lub hnub qub thiab kev tshawb fawb tsom mus rau kev tiv thaiv kab mob hauv lub cev. lub thib ob ib nrab ntawm lub xyoo pua 20th.
Mechanism ntawm kev ua ntawm paclitaxel
Paclitaxel inhibits kev loj hlob ntawm cov qog nqaij hlav cancer feem ntau los ntawm kev ua rau lub voj voog ntawm tes thiab ua rau muaj kev puas tsuaj mitotic.Nws cov tshiab thiab cov qauv tshuaj complex muab nws ib tug tshwj xeeb lom mechanism ntawm kev txiav txim.Paclitaxeltuaj yeem inhibit cell proliferation los ntawm inhibiting lub polymerization ntawm tubulin thiab rhuav tshem lub cell microtubule network.Tsis tas li ntawd, paclitaxel tseem tuaj yeem ua rau muaj kev cuam tshuam ntawm cov neeg kho mob pro-apoptotic thiab tswj cov kev ua haujlwm ntawm cov neeg kho mob los tiv thaiv apoptotic, yog li inducing apoptosis ntawm cov qog nqaij hlav cancer.
Kev tiv thaiv qog noj ntshav ntawm paclitaxel
Paclitaxel tau nyiam ntau xim vim nws cov kev ua haujlwm siab thiab tsis muaj tshuaj lom ntawm cov tshuaj tiv thaiv kab mob.Hauv kev xyaum kho mob, paclitaxel tau pom tias muaj txiaj ntsig zoo rau ntau yam qog noj ntshav, suav nrog mob qog noj ntshav mis, qog noj ntshav ntawm zes qe menyuam, qee qhov qog nqaij hlav taub hau thiab caj dab, thiab mob ntsws cancer.Los ntawm nws cov txheej txheem lom neeg tshwj xeeb, paclitaxel tuaj yeem cuam tshuam kev loj hlob ntawm cov qog nqaij hlav cancer thiab ua rau apoptosis ntawm cov qog nqaij hlav cancer.Tsis tas li ntawd, kev tiv thaiv kab mob qog noj ntshav ntawm paclitaxel kuj tseem cuam tshuam nrog nws lub peev xwm los tswj kev tiv thaiv kab mob ntawm cov qog hlwb.
Cov peev txheej tsis txaus ntawm paclitaxel
Txawm hais tias paclitaxel muaj cov haujlwm tseem ceeb hauv kev tiv thaiv kabmob, nws cov peev txheej tsis txaus tau txwv nws txoj kev siv tshuaj kho mob thoob plaws.Paclitaxel feem ntau yog muab rho tawm los ntawm Pacific yew ntoo, thiab vim tsis muaj peev txheej ntuj, kev tsim cov paclitaxel nyob deb ntawm kev ua raws li kev kho mob.Yog li ntawd, kev tshawb nrhiav qhov chaw tshiab ntawm paclitaxel, xws li kev tsim cov paclitaxel los ntawm biosynthesis lossis tshuaj synthesis, yog qhov tseem ceeb ntawm kev tshawb fawb tam sim no.
xaus
Raws li ib tug natural tshuaj anticancer,paclitaxelmuaj cov yam ntxwv ntawm kev ua haujlwm siab, tsis muaj tshuaj lom thiab dav spectrum, thiab nws cov kev ua haujlwm lom neeg tshwj xeeb ntawm kev ua haujlwm thiab kev ua haujlwm tseem ceeb ntawm kev tiv thaiv kab mob ua rau nws yog ib qho tseem ceeb ntawm kev kho mob qog noj ntshav hauv kev kho mob.Txawm li cas los xij, vim qhov tsis txaus ntawm nws cov peev txheej, nws txoj kev siv dav hauv kev kho mob tsuas yog txwv.Yog li ntawd, kev tshawb fawb yav tom ntej yuav tsum tsom mus nrhiav qhov chaw tshiab ntawm paclitaxel kom tau raws li kev xav tau ntawm kev kho mob thiab muab ntau txoj kev kho mob rau cov neeg mob qog noj ntshav.
Nco tseg: Cov txiaj ntsig zoo thiab cov ntawv thov uas tau nthuav tawm hauv kab lus no yog muab los ntawm cov ntaub ntawv luam tawm.
Post lub sij hawm: Nov-24-2023