Paclitaxel yog ib qho tshuaj tseem ceeb uas siv dav hauv kev kho mob qog noj ntshav, tab sis nws cov peev txheej ntuj raug txwv.Txhawm rau ua kom tau raws li qhov xav tau ntawm paclitaxel hauv khw muag tshuaj, cov kws tshawb fawb tau tshawb fawb ntau, nrog rau cov txheej txheem semi-synthetic los ua ib qho tseem ceeb ntawm kev tsim khoom.Tsab ntawv xov xwm no yuav qhia txog cov txheej txheem ntawm semi-synthesizing paclitaxel los ntawm 10-deacetylbaccatin III (10-DAB) thiab hais txog nws qhov tseem ceeb hauv kev siv tshuaj synthesis.
Paclitaxel, Ameslikas cais los ntawm cov tawv ntoo ntawm Pacific yew ntoo, muaj npe nrov rau nws cov khoom tiv thaiv kabmob kheesxaws.Txawm li cas los xij, Pacific yew yog cov peev txheej ntuj tsim nyog, tsis txaus los ua kom tau raws li qhov kev thov kho mob niaj hnub no rau paclitaxel.Txoj kev loj hlob ntawm cov txheej txheem semi-synthetic tau ua rau cov khoom loj ntawm paclitaxel ua tau, nrog 10-deacetylbaccatin III yog qhov tseem ceeb nruab nrab.
Kev npaj ntawm 10-DAB hauv Semi-Synthetic Paclitaxel:
10-DAB yog ib qho tseem ceeb hauv nruab nrab ntawm txoj kev semi-synthetic rau paclitaxel thiab yuav tsum muaj ob peb kauj ruam rau nws qhov kev npaj.Feem ntau, cov synthesis ntawm 10-DAB pib nrog lub ntuj precursor ntawm paclitaxel, taxuyunnanine C, muab los ntawm baccatin III.Baccatin III yog thawj zaug deacetylated los ua 10-deacetylbaccatin III.Tom qab ntawd, 10-deacetylbaccatin III tau dhau los ua ntau yam tshuaj tiv thaiv, suav nrog hydrogenation, hloov pauv, epoxidation, hydrolysis, thiab lwm yam, thaum kawg hloov mus rau 10-DAB.
Daim ntawv thov ntawm 10-DAB hauv Semi-Synthetic Paclitaxel:
Lub synthesis ntawm 10-DAB tau qhib ib txoj kev tshiab rau lub semi-synthesis ntawm paclitaxel, muab kev ruaj ntseg hauv kev tsim tshuaj.Paclitaxel yog cov tshuaj tiv thaiv kab mob dav dav siv los kho ntau yam mob qog noj ntshav, suav nrog zes qe menyuam, lub mis, thiab mob ntsws cancer.Txoj kev semi-synthetic txo tus nqi ntawm kev tsim tshuaj, ua rau qhov kev kho mob tseem ceeb no nkag mus rau cov neeg mob.
Xaus:
Cov txheej txheem ntawm semi-synthesizing paclitaxel los ntawm 10-DAB tau ua tiav cov txiaj ntsig tseem ceeb hauv kev siv tshuaj synthesis.Nws tsis tsuas yog hais txog qhov teeb meem ntawm cov peev txheej ntuj rau paclitaxel tab sis kuj tseem txhim kho kev tsim khoom thiab kev ruaj khov.Cov thev naus laus zis no sawv cev rau qhov tseem ceeb hauv kev tsim cov tshuaj tiv thaiv kab mob cancer thiab tuav cov lus cog tseg rau kev nce qib ntxiv hauv kev kho mob txhawm rau tiv thaiv cov kab mob loj xws li mob qog noj ntshav.Nyob rau hauv lub neej yav tom ntej, cov kws tshawb fawb yuav txuas ntxiv kho cov txheej txheem synthesis los txhim kho kev ua tau zoo thiab txo cov nqi, thaum kawg tau txais txiaj ntsig ntau ntawm cov neeg mob.
Nco tseg: Cov txiaj ntsig zoo thiab cov ntawv thov uas tau hais hauv kab lus no yog ua raws li cov ntaub ntawv uas muaj rau pej xeem.
Nyeem ntxiv: Yunnan Hande Biotech Co., Ltd., nrog 26 xyoo ntawm kev tsom mus rau paclitaxel ntau lawm, yog lub chaw tsim khoom lag luam thoob ntiaj teb pom zoo ntawm cov nroj tsuag rho tawm cov tshuaj tiv thaiv kab mob paclitaxel cov khoom xyaw tshuaj nquag, tau lees paub los ntawm cov koom haum tswj hwm xws li US FDA, European EDQM , Australia TGA, Tuam Tshoj CFDA, Is Nrias teb, Nyiv, thiab lwm yam.Yunnan Hande Paclitaxel, muaj nyob rau hauv Tshuag, yog muag ncaj qha los ntawm cov khw.Thov koj xav hu rau cov lus nug ntawm +86 18187887160 (WhatsApp).
Post lub sij hawm: Oct-24-2023